Federal Agencies Brace for Deep Cuts Post-'Cliff'


Dec 7, 2012 4:22pm







gty barack obama john boehner ll 121206 wblog Federal Agencies Brace for Deep Cuts Post Cliff

Toby Jorrin/AFP/Getty Images


With the “fiscal cliff” quickly approaching, federal agencies are stepping up preparations for deep automatic budget cuts that will kick in Jan. 2 unless the White House and Congress can reach a deal.


The Office of Management and Budget told ABC News that a memo went out to federal agencies earlier this week seeking “additional information and analysis” in order to finalize spending cuts required if we go off the cliff.


The agencies are considering which workers to furlough, projects to put on hold and offices that will have to close.


The request follows the administration’s release of a 400-page report in September that outlined the budget areas to be impacted by the $1.2 trillion in automatic spending cuts and what percentages they would be slashed.


READ MORE: White House Details ‘Doomsday’ Budget Cuts


Billions of dollars could be slashed from defense operations and maintenance programs. Medicare would take a two-percent hit, trimming millions in payouts to health care providers. Scientific research programs would be gutted. Aid for the poor and needy would be sharply curtailed.


The report also detailed operations that would be exempt from any cuts, including active-duty military operations, nuclear watchdogs, homeland security officials, veterans care and other critical areas.


READ: Pentagon Begins Planning for ‘Cliff’ Cuts


Asked about the agency preparations underway, White House spokesman Jay Carney said Wednesday that OMB “must take certain steps to ensure the administration is ready to issue such an order should Congress fail to act.”


“Earlier this week, OMB issued a request to federal agencies for additional information to finalize calculations on the spending reductions that would be required,” Carney said.


“This action should not be read … as a change in the administration’s commitment to reach an agreement and avoid sequestration.  OMB is simply ensuring that the administration is prepared, should it become necessary to issue such an order,” he said. “OMB will continue to consult with agencies and will provide additional guidance as needed.  This is just acting responsibly because of the potential for this happening.”


Get more pure politics at ABCNews.com/Politics and a lighter take on the news at OTUSNews.com.


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Egyptian opposition to shun Mursi's national dialogue


CAIRO (Reuters) - President Mohamed Mursi was expected to press ahead on Saturday with talks on ways to end Egypt's worst crisis since he took office even though the country's main opposition leaders have vowed to stay away.


Cairo and other cities have been rocked by violent protests since November 22, when Mursi promulgated a decree awarding himself sweeping powers that put him above the law.


The upheaval in the most populous Arab nation, following the fall of Hosni Mubarak last year, worries the West, in particular the United States, which has given it billions of dollars in military and other aid since Egypt made peace with Israel in 1979.


Mursi's deputy raised the possibility that a referendum set for December 15 on a new constitution opposed by liberals might be delayed. But the concession only goes part-way towards meeting the demands of the opposition, who also want Mursi to scrap the decree awarding himself wide powers.


On Friday, large crowds of protesters surged around the presidential palace, breaking through barbed wire barricades and climbing on tanks guarding the seat of Egypt's first freely elected president, who took office in June.


As the night wore on, tens of thousands of opposition supporters were still at the palace, waving flags and urging Mursi to "Leave, leave".


"AS LONG AS IT TAKES"


"We will stay here for as long as it takes and will continue to organize protests elsewhere until President Mursi cancels his constitutional decree and postpones the referendum," said Ahmed Essam, 28, a computer engineer and a member of the liberal Dostour party.


Vice President Mahmoud Mekky issued a statement saying the president was prepared to postpone the referendum if that could be done without legal challenge.


Mursi's planned dialogue meeting was expected to go ahead on Saturday in the absence of most opposition factions. "Everything will be on the table," a presidential source said.


Mursi could be joined by some senior judiciary figures and politicians such as Ayman Nour, one of the candidates in Mubarak's only multi-candidate presidential race, in 2005, in which he was unsurprisingly trounced.


The opposition has demanded that Mursi rescind the decree giving himself wide powers and delay the vote set for December 15 on a constitution drafted by an Islamist-led assembly which they say fails to meet the aspirations of all Egyptians.


EXPAT VOTE DELAYED


The state news agency reported that the election committee had postponed the start of voting for Egyptians abroad until Wednesday, instead of Saturday as planned. It did not say whether this would affect the timing of voting within Egypt.


Ahmed Said, leader of the liberal Free Egyptians Party, told Reuters that delaying expatriate voting was intended to seem like a concession but would not change the opposition's stance.


The opposition organized marches converging on the palace which Republican Guard units had ringed with tanks and barbed wire on Thursday after violence between supporters and opponents of Mursi killed seven people and wounded 350.


Islamists, who had obeyed a military order for demonstrators to leave the palace environs, held funerals on Friday at Cairo's al-Azhar mosque for six Mursi partisans who were among the dead.


"With our blood and souls, we sacrifice to Islam," they chanted.


A group led by leftist opposition leader Hamdeen Sabahy has called for an open-ended protest at the palace.


Some pro-Mursi demonstrators gathered in a mosque not far from the palace, but said they would not march towards the palace to avoid a repeat of the violence that took place on Wednesday night.


In a speech late on Thursday, Mursi had refused to retract his decree or cancel the referendum on the constitution, but offered talks on the way forward after the referendum.


The National Salvation Front, the main opposition coalition, said it would not join the dialogue. The Front's coordinator, Mohamed ElBaradei, a Nobel peace laureate, dismissed the offer as "arm-twisting and imposition of a fait accompli".


ElBaradei said that if Mursi were to scrap the decree with which he awarded himself extra powers and postpone the referendum "he will unite the national forces".


Murad Ali, spokesman for the Muslim Brotherhood's Freedom and Justice Party, said opposition reactions were sad: "What exit to this crisis do they have other than dialogue?" he asked.


(This story corrects Mursi's title to president in paragraph 1)


(Additional reporting by Omar Fahmy; Writing by Giles Elgood; Editing by Michael Roddy and Paul Tait)



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Resale prices of non-landed private residential, HDB flats at new highs in Oct & Nov






SINGAPORE: Resale home prices of both non-landed private residential units and HDB flats continued to climb to new highs in October and November against the third quarter 2012.

But according to data released by the Singapore Real Estate Exchange (SRX), the rental market for private homes is showing signs of softening.

As a result, overall gross rental yield dropped to a six-year historic low of 3.77 per cent in the first two months of the fourth quarter.

Meanwhile, prices of private resale homes rose to S$1,222 per square foot (psf) in the first two months of the fourth quarter, up 5.4 per cent from the previous quarter's average of S$1,159 psf.

The report found that resale prices of private homes rose across all regions, with non-landed homes in the suburban region seeing the sharpest increase at 4.5 per cent, compared to the third quarter of 2012.

This is followed by a 3.3 per cent increase in the city fringes and a 2.8 per cent increase in the core central region.

Compared with the first two months of the third quarter this year, transaction volume rose by 6 per cent to reach 2,483 resale transactions in the October to November period.

Meanwhile, the average unit monthly rent of private homes dropped by 1.0 per cent, from S$3.88 psf in the third quarter to S$3.84 in the first two months of forth quarter.

Leading the drop is non-landed homes in the city fringe where prices fell by 2.5 per cent to S$3.91 after rising for the first three consecutive quarters in this year.

The other regions remained relatively stable compared to the previous quarter.

Meanwhile, the report included for the first time data about the sales of small private apartments, commonly known as shoebox units in Singapore.

Year-to-date, just 198 shoebox units changed hands in the resale market.

But the report said there was strong demand for rentals of shoebox units, with 1,328 rental contracts signed this year. This represents 6.7 times more rentals than resales for shoebox units year-to-date. In contrast, the average is 2.4 times more rentals than resales for other types of units.

As a result, shoebox units continue to draw higher rental offers in the fourth quarter.

In the HDB resale market, SRX said overall cash-over-valuation rose to S$34,000 in the first two months into forth quarter. This is S$2,000 shy of the five-year historical high of S$36,000 attained in the third quarter of 2011 since tracking began in 2007.

On a month-to-month basis, overall COV increased from S$33,000 in October to S$35,000 in November.

This has contributed to a 1.1 increase in median prices of HDB flats to a new high of S$455,000, compared to the third quarter.

Overall HDB median rents remained unchanged at S$2,400.

- CNA/ck



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Ajit Pawar sworn in as Maharashtra deputy chief minister

MUMBAI: A week after a government white paper on irrigation gave Ajit Pawar a clean chit, the senior NCP leader was on Friday sworn in as Maharashtra deputy chief minister.

Pawar, the nephew of NCP president and Union minister Sharad Pawar, was sworn in at Raj Bhawan here.

Governor K Sankaranarayanan administered oath of office to Pawar in the presence of chief minister Prithviraj Chavan.

Opposition Sena-BJP members, which have denounced the move, kept away from the swearing-in ceremony.

The dramatic announcement of resignation of Pawar on September 25, in the wake of allegations of corruption in irrigation projects, had plunged the state's Congress-NCP government into a crisis with all other 19 party ministers offering to quit.

Pawar, 53, had resigned after media reports alleged he had arbitrarily awarded irrigation contracts worth over Rs 20,000 crore when he was state's irrigation minister during 1999-2009, before he was elevated as deputy chief minister and handled the plum finance and energy portfolios.

The white paper, presented by the irrigation department to the state Cabinet on November 29, had claimed a 28 per cent increase in irrigation potential in Maharashtra in the last ten years.

It was described as a status paper on irrigation and not an investigation report.

Chavan had announced a white paper on irrigation would be brought after state's economic survey report said the state's irrigation potential had risen only by 0.1 per cent between 2001 and 2010.

All these years the irrigation portfolio was with the NCP.

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Celebrations planned as Wash. legalizes marijuana


SEATTLE (AP) — Legal marijuana possession becomes a reality under Washington state law on Thursday, and some people planned to celebrate the new law by breaking it.


Voters in Washington and Colorado last month made those the first states to decriminalize and regulate the recreational use of marijuana. Washington's law takes effect Thursday and allows adults to have up to an ounce of pot — but it bans public use of marijuana, which is punishable by a fine, just like drinking in public.


Nevertheless, some people planned to gather at 12:01 a.m. PST Thursday to smoke in public beneath Seattle's Space Needle. Others planned a midnight party outside the Seattle headquarters of Hempfest, the 21-year-old festival that attracts tens of thousands of pot fans every summer.


"This is a big day because all our lives we've been living under the iron curtain of prohibition," said Hempfest director Vivian McPeak. "The whole world sees that prohibition just took a body blow."


In another sweeping change for Washington, Gov. Chris Gregoire on Wednesday signed into law a measure that legalizes same-sex marriage. The state joins several others that allow gay and lesbian couples to wed.


That law also takes effect Thursday, when gay and lesbian couples can start picking up their wedding certificates and licenses at county auditors' offices. Those offices in King County, the state's largest and home to Seattle, and Thurston County, home to the state capital of Olympia, planned to open the earliest, at 12:01 a.m. Thursday, to start issuing marriage licenses. Because the state has a three-day waiting period, the earliest that weddings can take place is Sunday.


The Seattle Police Department provided this public marijuana use enforcement guidance to its officers via email Wednesday night: "Until further notice, officers shall not take any enforcement action — other than to issue a verbal warning — for a violation of Initiative 502."


Thanks to a 2003 law, marijuana enforcement remains the department's lowest priority. Even before I-502 passed on Nov. 6, police rarely busted people at Hempfest, despite widespread pot use, and the city attorney here doesn't prosecute people for having small amounts of marijuana.


Officers will be advising people to take their weed inside, police spokesman Jonah Spangenthal-Lee wrote on the SPD Blotter. "The police department believes that, under state law, you may responsibly get baked, order some pizzas and enjoy a 'Lord of the Rings' marathon in the privacy of your own home, if you want to."


Washington's new law decriminalizes possession of up to an ounce for those over 21, but for now selling marijuana remains illegal. I-502 gives the state a year to come up with a system of state-licensed growers, processors and retail stores, with the marijuana taxed 25 percent at each stage. Analysts have estimated that a legal pot market could bring Washington hundreds of millions of dollars a year in new tax revenue for schools, health care and basic government functions.


But marijuana remains illegal under federal law. That means federal agents can still arrest people for it, and it's banned from federal properties, including military bases and national parks.


The Justice Department has not said whether it will sue to try to block the regulatory schemes in Washington and Colorado from taking effect.


"The department's responsibility to enforce the Controlled Substances Act remains unchanged," said a statement issued Wednesday by the Seattle U.S. attorney's office. "Neither states nor the executive branch can nullify a statute passed by Congress" — a non-issue, since the measures passed in Washington and Colorado don't "nullify" federal law, which federal agents remain free to enforce.


The legal question is whether the establishment of a regulated marijuana market would "frustrate the purpose" of the federal pot prohibition, and many constitutional law scholars say it very likely would.


That leaves the political question of whether the administration wants to try to block the regulatory system, even though it would remain legal to possess up to an ounce of marijuana.


Colorado's measure, as far as decriminalizing possession goes, is set to take effect by Jan. 5. That state's regulatory scheme is due to be up and running by October 2013.


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Johnson can be reached at https://twitter.com/GeneAPseattle


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John McAfee Out of Hospital, Back in Cell













Software millionaire John McAfee has been returned to an immigration detention cell in Guatemala after being rushed to a Guatemala City hospital via ambulance.


McAfee, 67 -- who soon may be deported back to Belize, where authorities want to question him about the shooting death of his neighbor -- was reportedly found prostrate on the floor of his cell and unresponsive.


He was wheeled into the hospital on a gurney. Photographers followed in pursuit right into the emergency room, but as emergency workers eased McAfee's limp body from the gurney and onto a bed and began to remove his suit, he suddenly spoke up, saying, "Please, not in front of the press."


Earlier today, McAfee had complained of chest pains, raising concerns he might be having a heart attack.


However, that did not appear to be the case. Hours after his emergency, hospital officials sent McAfee back to the detention center, telling ABC News they found no reason to keep him overnight.


In a phone interview overnight, McAfee told ABC News, "I simply passed out, everything went black."


He said he hit his head on the floor when he collapsed. McAfee explained that for the past 48 hours he hasn't eaten and had very little to drink.


McAfee had been scheduled to be deported to Belize, ABC News has learned. But a judge could stay the ruling if it is determined that McAfee's life is threatened by being in Belizean custody, as McAfee has claimed in the past several weeks.


McAfee's attorneys hope to continue delaying the deportation by appealing to the Guatemala's high court on humanitarian grounds.


Raphael Martinez, a spokesman for the Belize government, said that if McAfee is deported to Belize, he would immediately be handed over to police and detained for up to 48 hours unless charges are brought against him.


"There is more that we know about the investigation, but that remains part of the police work," he said, hinting at possible charges.


He added that a handover by Guatemala would be "the neighborly thing to do."


A spokesman for the U.S. embassy in Guatemala said that "due to privacy considerations," the embassy would "have no comment on the specifics of this situation," but that, "U.S. citizens are subject to the laws of the countries in which they are traveling or residing, and must work within the host countries' legal framework."






Guatemala's National Police/AP Photo













Software Founder Breaks Silence: McAfee Speaks on Murder Allegations Watch Video









John McAfee Interview: Software Mogul Leaves Belize Watch Video





Just hours before McAfee's arrest, he told ABC News in an exclusive interview Wednesday he would be seeking asylum in Guatemala. McAfee was arrested by the Central American country's immigration police and not the national police, said his attorney, who was confident his client would be released within hours.


"Thank God I am in a place where there is some sanity," said McAfee before his arrest. "I chose Guatemala carefully."


McAfee said that in Guatemala, the locals aren't surprised when he says the Belizean government is out to kill him.


"Instead of going, 'You're crazy,' they go, 'Yeah, of course they are,'" he said. "It's like, finally, I understand people who understand the system here."


But McAfee added he has not ruled out moving back to the United States, where he made his fortune as the inventor of anti-virus software, and that despite losing much of his fortune he still has more money than he could ever spend.


In his interview with ABC News, a jittery, animated but candid McAfee called the media's representation of him a "nightmare that is about to explode," and said he's prepared to prove his sanity.


McAfee has been on the run from police in Belize since the Nov. 10 murder of his neighbor, fellow American expatriate Greg Faull.


During his three-week journey, said McAfee, he disguised himself as handicapped, dyed his hair seven times and hid in many different places during his three-week journey.


He dismissed accounts of erratic behavior and reports that he had been using the synthetic drug bath salts. He said he had never used the drug, and said statements that he had were part of an elaborate prank.


Investigators said that McAfee was not a suspect in the death of the former developer, who was found shot in the head in his house on the resort island of San Pedro, but that they wanted to question him.


McAfee told ABC News that the poisoning death of his dogs and the murder just hours later of Faull, who had complained about his dogs, was a coincidence.


McAfee has been hiding from police ever since Faull's death -- but Telesforo Guerra, McAfee's lawyer in Guatemala, said the tactic was born out of necessity, not guilt.


"You don't have to believe what the police say," Guerra told ABC News. "Even though they say he is not a suspect they were trying to capture him."


Guerra, who is a former attorney general of Guatemala, said it would take two to three weeks to secure asylum for his client.


According to McAfee, Guerra is also the uncle of McAfee's 20-year-old girlfriend, Samantha. McAfee said the government raided his beachfront home and threatened Samantha's family.


"Fifteen armed soldiers come in and personally kidnap my housekeeper, threaten Sam's father with torture and haul away half a million dollars of my s***," claimed McAfee. "If they're not after me, then why all these raids? There've been eight raids!"


Before his arrest, McAfee said he would hold a press conference on Thursday in Guatemala City to announce his asylum bid. He has offered to answer questions from Belizean law enforcement over the phone, and denied any involvement in Faull's death.






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Philippines starts to bury dead as toll hits 418


NEW BATAAN, Philippines (Reuters) - Residents in the southern Philippines began to bury their dead on Friday even as rescue workers continued scouring remote areas for possible survivors of Typhoon Bopha, the country's strongest storm this year, which killed 418 people and left nearly as many missing.


Officials in Compostela Valley, one of the worst hit provinces on the resource-rich island of Mindanao, were considering mass graves for unclaimed bodies killed by the typhoon which hit two days ago.


Bopha cut a swath of destruction in the valley, flooding farming and mining towns and burying many people in mudslides.


"We are thinking of burying the unclaimed bodies on health concerns," Major General Ariel Bernardo, an army division commander in the southern Philippines, told Reuters. "The foul smell is becoming strong."


Bernardo said rescue and retrieval work was hampered by lack of equipment. "Some of the dead are buried in knee deep mud and we only have our hands and shovels," he said.


Arturo Uy, governor of Compostela Valley, said the province was considering digging mass graves if most of the dead are not claimed in two to three days. He estimates 212 died in his province while nearly 400 were missing.


"Probably half of the missing could be dead by now," he told Reuters.


The official death toll stands at 418, with 383 missing and hundreds injured, the national disaster agency said in its latest tally. But the toll is expected to rise, with local government officials quoting higher numbers of missing.


A Reuters photographer saw at least 10 bodies under mud and piles of logs and debris and only a few hundreds of meters from a crowded makeshift grandstand in New Bataan town in Compostela Valley, where President Benigno Aquino was due to give out relief goods later on Friday.


"Up to now, we are not discussing stopping (the search)," Uy told reporters. "There are still survivors in barangays (villages) which we couldn't reach immediately."


Stephen Antig, executive director of Pilipino Banana Growers and Exporters Association, estimates about 7 billion pesos ($171 million) worth of bananas mostly for export in Compostela Valley and Davao del Norte were destroyed by the typhoon.


The area, where plantations owned by Dole Food Company Inc and Del Monte Pacific Ltd are located, accounts for almost a fifth of the country's total banana production.


Bopha has now weakened and is slowly moving north-northwest towards the South China Sea, with central winds of up to 110 kph (68 mph) and gusts of up to 140 kph (87 mph).


About 20 typhoons hit the Philippines every year, often causing death and destruction. Almost exactly a year ago, Typhoon Washi killed 1,500 people in Mindanao, but most storms make landfall further north.


($1 = 40.965 Philippine pesos)


(Additional reporting by Rosemarie Francisco, Manny Mogato and Erik dela Cruz; Editing by Michael Perry)



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4 ex-SMRT bus drivers from China charged with instigating strike granted bail






SINGAPORE: The four ex-SMRT drivers from China who have been charged with instigating an illegal strike have been granted bail on Thursday.

He Jun Ling, who faces two charges of inciting SMRT drivers to take part in the strike on 26 and 27 November, was granted bail of S$20,000. His passport will have to be impounded.

According to court documents, He, 32, also made an online post about the strike on Chinese website Baidu, allegedly asking other workers to go on MC together.

Gao Yue Qiang, 32, Wang Xian Jie, 39 and Liu Xiang Ying, 33, were granted bail of S$10,000 each. Their passports will have to be impounded.

In response to a question from District Judge May Lucius Mesenas, the four accused said they're not able to raise the money.

Two officials from the Chinese embassy were present in court.

- CNA/ck



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Sonia, Manmohan in top 20; Obama most powerful person: Forbes 2012 power list

NEW YORK: Prime Minister Manmohan Singh and Congress president Sonia Gandhi have been named among the top 20 most powerful persons in the world by Forbes magazine in its annual power rankings which placed US President Barack Obama as number one for a second year in a row.

India's richest businessman Reliance Industries chairman Mukesh Ambani and and Arcelor Mittal CEO Lakshmi Mittal also feature in the list that comprises 71 mighty heads of state, CEOs, entrepreneurs and philanthropists who "truly run and shape the world of 7.1 billion people."

Gandhi dropped a notch from last year's list and ranks at number 12 this year ahead of Chinese Vice-Premier Li Keqiang and French President Francois Hollande.

Forbes said the 65-year-old leader of India's ruling political party has the reins of the world's second-most-populous country and tenth-largest economy.

"Son Rahul is next in line to take over India's most famous political dynasty," it added.

Coming in at the 20th spot is Singh, the Oxford and Cambridge-educated economist who is the architect of India's economic reforms.

Singh had ranked 19th in the list last year. "But Singh's quiet intellectualism is increasingly seen as timid and soft," Forbes added.

Ambani, owner of the world's most expensive private residence, ranks 37th in the list. Forbes said the petrochemical billionaire is India's richest and Reliance Industries is the nation's most valuable company.

It however described Ambani's support for disgraced former Goldman Sachs director Rajat Gupta as a "low point" for him in 2012.

Mittal, ranked 47th in the most powerful people list, has a net worth of USD 16 billion but also has "lots of headaches, including S&P and Moody downgrades of his company's debt to junk status." A highlight for Mittal during the past year was carrying the Olympic flame in the 2012 torch relay.

Forbes said 51-year-old Obama emerged "unanimously" as the world's most powerful person for the second year running.

The decisive winner of the 2012 US presidential election, Obama now has four more years to push his agenda even as he faces major challenges, including an unresolved budget crisis, stubbornly high unemployment and renewed unrest in the Middle East.

"But Obama remains the commander-in-chief of the world's greatest military and head of the sole economic and cultural superpower--literally the leader of the free world," it said.

The second most powerful person in the world also happens to be the most powerful woman, German chancellor 58-year-old Angela Merkel. She jumped up from the number four position last year to take the runner-up spot on the 2012 list.

Forbes termed Merkel as the backbone of the 27-member European Union, one who carries the fate of the Euro on her shoulders.

The list also includes Russian President Vladimir Putin at number three, Microsoft co-founder Bill Gates (4), General Secretary of the Chinese Communist Party Xi Jinping (9), Google co-founders Larry Page and Sergey Brin (20), Iran's supreme leader Ali Khamenei (21) UN chief Ban Ki-moon (30), North Korean leader Kim Jong-un (44) and former US President Bill Clinton (50).

Forbes dropped US secretary of state Hillary Clinton from the list this year. Clinton, who had ranked 16th last year, does not feature in 2012 rankings as she is not expected to return to her powerful post for Obama's second term.

It is for the same reason that US treasury secretary Timothy Geithner also does not feature in this year's list.

Pakistan's Chief of Army Staff Ashfaq Parvez Kayani is ranked 28th in the list.

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Study could spur wider use of prenatal gene tests


A new study sets the stage for wider use of gene testing in early pregnancy. Scanning the genes of a fetus reveals far more about potential health risks than current prenatal testing does, say researchers who compared both methods in thousands of pregnancies nationwide.


A surprisingly high number — 6 percent — of certain fetuses declared normal by conventional testing were found to have genetic abnormalities by gene scans, the study found. The gene flaws can cause anything from minor defects such as a club foot to more serious ones such as mental retardation, heart problems and fatal diseases.


"This isn't done just so people can terminate pregnancies," because many choose to continue them even if a problem is found, said Dr. Ronald Wapner, reproductive genetics chief at Columbia University Medical Center in New York. "We're better able to give lots and lots of women more information about what's causing the problem and what the prognosis is and what special care their child might need."


He led the federally funded study, published in Thursday's New England Journal of Medicine.


A second study in the journal found that gene testing could reveal the cause of most stillbirths, many of which remain a mystery now. That gives key information to couples agonizing over whether to try again.


The prenatal study of 4,400 women has long been awaited in the field, and could make gene testing a standard of care in cases where initial screening with an ultrasound exam suggests a structural defect in how the baby is developing, said Dr. Susan Klugman, director of reproductive genetics at New York's Montefiore Medical Center, which enrolled 300 women into the study.


"We can never guarantee the perfect baby but if they want everything done, this is a test that can tell a lot more," she said.


Many pregnant women are offered screening with an ultrasound exam or a blood test that can flag some common abnormalities such as Down syndrome, but these are not conclusive.


The next step is diagnostic testing on cells from the fetus obtained through amniocentesis, which is like a needle biopsy through the belly, or chorionic villus sampling, which snips a bit of the placenta. Doctors look at the sample under a microscope for breaks or extra copies of chromosomes that cause a dozen or so abnormalities.


The new study compared this eyeball method to scanning with gene chips that can spot hundreds of abnormalities and far smaller defects than what can be seen with a microscope. This costs $1,200 to $1,800 versus $600 to $1,000 for the visual exam.


In the study, both methods were used on fetal samples from 4,400 women around the country. Half of the moms were at higher risk because they were over 35. One-fifth had screening tests suggesting Down syndrome. One-fourth had ultrasounds suggesting structural abnormalities. Others sought screening for other reasons.


"Some did it for anxiety — they just wanted more information about their child," Wapner said.


Of women whose ultrasounds showed a possible structural defect but whose fetuses were called normal by the visual chromosome exam, gene testing found problems in 6 percent — one out of 17.


"That's a lot. That's huge," Klugman said.


Gene tests also found abnormalities in nearly 2 percent of cases where the mom was older or ultrasounds suggested a problem other than a structural defect.


Dr. Lorraine Dugoff, a University of Pennsylvania high-risk pregnancy specialist, wrote in an editorial in the journal that gene testing should become the standard of care when a structural problem is suggested by ultrasound. But its value may be incremental in other cases and offset by the 1.5 percent of cases where a gene abnormality of unknown significance is found.


In those cases, "a lot of couples might not be happy that they ordered that test" because it can't give a clear answer, she said.


Ana Zeletz, a former pediatric nurse from Hoboken, N.J., had one of those results during the study. An ultrasound suggested possible Down syndrome; gene testing ruled that out but showed an abnormality that could indicate kidney problems — or nothing.


"They give you this list of all the things that could possibly be wrong," Zeletz said. Her daughter, Jillian, now 2, had some urinary and kidney abnormalities that seem to have resolved, and has low muscle tone that caused her to start walking later than usual.


"I am very glad about it," she said of the testing, because she knows to watch her daughter for possible complications like gout. Without the testing, "we wouldn't know anything, we wouldn't know to watch for things that might come up," she said.


The other study involved 532 stillbirths — deaths of a fetus in the womb before delivery. Gene testing revealed the cause in 87 percent of cases versus 70 percent of cases analyzed by the visual chromosome inspection method. It also gave more information on specific genetic abnormalities that couples could use to estimate the odds that future pregnancies would bring those risks.


The study was led by Dr. Uma Reddy of the National Institute of Child Health and Human Development.


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Online:


Medical journal: http://www.nejm.org


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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP


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